Spam1-associated transmission ratio distortion in mice: elucidating the mechanism.

ABSTRACT:

Background

While transmission ratio distortion, TRD, (a deviation from Mendelian ratio) is extensive in humans and well-documented in mice, the underlying mechanisms are unknown. Our earlier studies on carriers of spontaneous mutations of mouse Sperm Adhesion Molecule 1 (Spam1) suggested that TRD results from biochemically different sperm, due to a lack of transcript sharing through the intercellular cytoplasmic bridges of spermatids. These bridges usually allow transcript sharing among genetically different spermatids which develop into biochemically and functionally equivalent sperm.

Objectives

The goals of the study were to provide support for the lack of sharing (LOS) hypothesis, using transgene and null carriers of Spam1, and to determine the mechanism of Spam1-associat

SUBMITTER: Martin-DeLeon PA 

PROVIDER: S-EPMC1201170 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature