Molecular mechanisms of the anchang group prescription in treating radiation enteritis: network pharmacology analysis and experimental evidence.

ABSTRACT:

Background

The "Anchang" Group Prescription (ACZF), based on the traditional Bai Tou Weng Decoction and Si Jun Zi Decoction, has demonstrated clinical efficacy in alleviating symptoms of radiation enteritis (RE). Nevertheless, the precise active components and their underlying molecular mechanisms in ACZF's effect on RE require further elucidation. This investigation seeks to delineate the active components and explore the molecular mechanisms by which ACZF mitigates RE, utilizing both network pharmacology and experimental approaches to provide a solid theoretical base for subsequent research and clinical applications.

Methods

Utilizing network pharmacology, this research constructed a comprehensive "drug-active ingredient-target gene-disease" model leveraging resources such

SUBMITTER: Liang W 

PROVIDER: S-EPMC12011760 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature