The associations between skin advanced glycation end-products and Framingham cardiovascular risk in different age groups.

ABSTRACT:

Objective

Advanced glycation end-products (AGEs) may contribute to the pathogenesis of atherosclerotic cardiovascular disease (ASCVD), potentially influencing its development and progression differently at various life stages. This study aimed to elucidate the associations between AGEs and the risk of ASCVD across different age groups.

Methods

In this cross-sectional study, 1,240 subjects were enrolled and divided into three groups (Group Ⅰ, 20-39 years old, n = 468; Group Ⅱ, 40-59 years old, n = 471; Group Ⅲ, 60-79 years old, n = 301). Skin AGEs were measured by skin autofluorescence (SAF). ASCVD risk was assessed by a validated Framingham risk score calculator. Other proven ASCVD risk factors were also measured, including glycosylated hemoglobin, uric

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12011794 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature