Swimming Into View: Zebrafish Uncover Targets, Mechanisms, and Therapies for Cadmium Toxicity.

ABSTRACT:

Purpose of review

Cadmium (Cd) remains a persistent threat to human and environmental health. To better understand causal relationships between genotype and disease phenotypes, a genetically tractable model, zebrafish (Danio rerio) has emerged. We summarize recent empirical evidence on the targets, mechanisms, and potential therapies for Cd toxicity.

Recent findings

Recent results show that waterborne Cd exhibits organ specific accumulation including in the eye, brain, heart, and gonads triggering oxidative stress, inflammation, gut dysbiosis, and altered methylation patterns that persist across generations. Novel mechanisms of Cd toxicity include the gut-brain axis, ionic antagonism, the Wnt/β-catenin pathway, and epigenetics, leading to potential therapeutics such as probi

SUBMITTER: Okutsu J 

PROVIDER: S-EPMC12011950 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature