Osteosarcopenia, osteoarthritis and frailty: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Musculoskeletal disease, which has a complicated relationship with frailty, is a common clinical problem among elderly individuals.

Aims

This study evaluated the potential causal relationships between osteosarcopenia, osteoarthritis and frailty by Mendelian Randomization (MR) analysis.

Methods

This study employed a two-sample MR approach to investigate the causal relationships among osteosarcopenia, osteoarthritis and frailty. Published summary statistics were used to obtain instrumental variables at the genome-wide significance level.

Results

Among the age groups with osteoporosis, high total bone mineral density (TBMD) (45-60, OR = 0.966, 95% CI 0.940-0.993, P = 0.013) and TBMD (over 60, OR = 0.974, 95% CI 0.954-0.994, P = 0.011) reduced the risk o

SUBMITTER: Liu J 

PROVIDER: S-EPMC12011954 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature