Differential changes in the microglial transcriptome between neonatal and adult mice after spinal cord injury.

ABSTRACT: Spinal cord injury (SCI) remains a significant therapeutic challenge, lacking effective treatment options. Related studies have found that neonatal microglia are more effective than adult microglia in promoting the recovery of SCI, but the reason why neonatal, not adult, microglia are more conducive to SCI recovery is not clear, the differences of gene expression and pathways between them are still worth exploring. Therefore, we examined changes in the microglial transcriptome after SCI in neonatal and adult mice. We identified hub genes or pathways that exhibited significant differential expression between the two groups. Four Gene sets were established for further analysis, named Gene set 1, Gene set 2, Gene set 3, Gene set 4, respectively. GO analysis revealed enrichment in categories c

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC12012053 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature