Microstructure is associated with motor outcomes following Deep Brain Stimulation in Parkinson's disease.

ABSTRACT: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established intervention for alleviating both motor and non-motor symptoms in advanced Parkinson's disease (PD). However, patient outcomes may vary widely, underscoring the need for predictive biomarkers. Neuroimaging techniques, such as neurite orientation dispersion and density imaging (NODDI), a biophysical model-based MRI technique, offer promise in forecasting clinical outcomes and supporting preoperative counseling. This prospective, open-label study aimed to identify microstructural markers that correlate with short-term motor outcomes following STN-DBS in PD patients. Thirty-five patients underwent diffusion MRI and comprehensive clinical evaluations preoperatively and six months postoperatively. Evaluations were per

SUBMITTER: Loehrer PA 

PROVIDER: S-EPMC12012084 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature