Genome-wide association analysis reveals insights into the genetic architecture of mesenteric torsion in pigs.

ABSTRACT: Mesenteric torsion (MT) is a condition that affects several animal species and can lead to the animals' death. However, little is known about its etiology. Therefore, this study aimed to identify genomic regions and candidate genes associated with MT. Phenotypic and genotypic data from 405 pigs, including MT records and genealogy were used. In the model, contemporary group (sex, year, and week of weaning) was considered fixed effect, the linear effect of weaning weight as a covariate, while direct additive genetic effect was random. In the genome-wide association study, genomic windows explaining more than 0.3% of the genetic variance were considered significant. Fifty-two significant windows were identified, covering 299 genes located on 15 chromosomes. The HSD17B4, TNFAIP8, TENM4, CHD2,

SUBMITTER: Padilha SF 

PROVIDER: S-EPMC12012111 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature