Intratumor fungi specific mechanisms to influence cell death pathways and trigger tumor cell apoptosis.

ABSTRACT: Cancer, uncontrolled cell growth due to the loss of cell cycle regulation, is often found to be associated with viral infections and, as recent studies show, with bacterial infections as well. Emerging reports also suggest a strong link between fungi and cancer. The crucial virulence trait of fungi, the switch from yeast (Y) to hyphal (H) form, is found to be associated with carcinogenesis. The physicochemical properties and signal transduction pathways involved in the switch to the hyphal form overlap with those of tumor cell formation. Inhibiting differentiation causes apoptosis in fungi, whereas preventing apoptosis leads to cancer in multicellular organisms. Literature on the fungi-cancer linkage, though limited, is increasing rapidly. This review examines cancer-specific fungal commun

SUBMITTER: Ghogare SS 

PROVIDER: S-EPMC12012188 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature