Acute Effects of Nicotine on Non-Drug-Related Reward in Smokers and Non-Smokers.

ABSTRACT:

Introduction

Nicotine increases the reward value of non-drug-related stimuli in animals and dependent smokers; however, research on people who are not dependent on nicotine is limited. This study aimed to explore whether nicotine delivered by oral spray can enhance responding to self-selected sensory rewards in both smokers and non-smokers.

Aims and methods

Minimally abstinent smokers (n = 30) and non-smokers (n = 31) completed subjective ratings of nicotine withdrawal, and received either 2 mg nicotine or placebo oral spray and visual analogue scales to measure the perceived effects of the spray. An operant conditioning task (Applepicker) that required button clicks to find apples was completed twice, with and without a reward of 30 seconds of pre-prepared music for each re

SUBMITTER: Rycroft N 

PROVIDER: S-EPMC12012236 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature