Association Between Plasma Amyloid-Beta 42 Ratio and Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery: Secondary Analysis of a Randomized Controlled Trial.

ABSTRACT:

Introduction

Cerebrospinal fluid Aβ42 has been proposed as a potential indicator for cerebral β-amyloidosis and may be involved in the pathophysiology of delirium. Whether perioperative plasma Aβ42 alternation is associated with postoperative delirium risk among elderly patients remains unknown.

Methods

This was a secondary analysis of a randomized controlled trial evaluating the effects of acupuncture (intervention) compared to standard care (control) on the incidence of delirium in patients undergoing major abdominal surgery. Participants with blood samples collected were included in this cohort study. The exposure variable was the Aβ42 ratio, calculated with the plasma Aβ42 level immediately after surgery divided by the preoperative plasma Aβ42 level. The primary endpoint

SUBMITTER: Fan Q 

PROVIDER: S-EPMC12012251 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature