Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine-125 Plaque Radiotherapy Using a Novel Structural-Functional Imaging Analysis System.

ABSTRACT:

Background

To investigate the changes in retinal oxygen kinetics and hemodynamics in patients with choroidal melanoma (CM) within 2 years before and after iodine-125 plaque radiotherapy (PRT) using a novel noninvasive structure-functional imaging analysis system.

Methods

A novel noninvasive cost-effective imaging analysis system that integrates multimodal structural and functional retinal imaging techniques has been used, which allows rapid acquisition of vascular structural, hemodynamic, and oxygenation metrics using multispectral imaging (MSI) and laser speckle contrast imaging (LSCI) techniques. Follow-ups have been arranged at the time before plaque implantation surgery, and 1 month, 3 months, 6 months, 12 months, 18 months, and 24 months after iodine-125 plaque removal.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12012311 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature