Unknown

Dataset Information

0

Mapping of the binding site for Mannheimia haemolytica leukotoxin within bovine CD18.

ABSTRACT: To map the site involved in Mannheimia haemolytica leukotoxin (LktA) binding and biological activity within bovine CD18, bovine x human CD18 chimeric constructs were generated and coexpressed with bovine CD11a in K562 cells. Studies with the chimeric leukocyte function-associated antigen 1 transductants demonstrate that the site required for LktA binding and biological effects resides within amino acid residues 500 and 600 of the extracellular region of bovine CD18.

SUBMITTER: Dileepan T 

PROVIDER: S-EPMC1201247 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Mapping of the binding site for Mannheimia haemolytica leukotoxin within bovine CD18.

Dileepan T T   Kannan M S MS   Walcheck B B   Thumbikat P P   Maheswaran S K SK  

Infection and immunity 20050801 8

To map the site involved in Mannheimia haemolytica leukotoxin (LktA) binding and biological activity within bovine CD18, bovine x human CD18 chimeric constructs were generated and coexpressed with bovine CD11a in K562 cells. Studies with the chimeric leukocyte function-associated antigen 1 transductants demonstrate that the site required for LktA binding and biological effects resides within amino acid residues 500 and 600 of the extracellular region of bovine CD18. ...[more]

Similar Datasets

Unknown Mannheimia (Pasteurella) haemolytica leukotoxin binding domain lies within amino acids 1 to 291 of bovine CD18.
| S-EPMC1231049 | biostudies-literature
Unknown A bovine CD18 signal peptide variant with increased binding activity to Mannheimia hemolytica leukotoxin.
| S-EPMC6406179 | biostudies-literature
Unknown Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
| S-EPMC2741271 | biostudies-literature
Unknown Inflammatory cytokines enhance the interaction of Mannheimia haemolytica leukotoxin with bovine peripheral blood neutrophils in vitro.
| S-EPMC128205 | biostudies-literature
Unknown Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells.
| S-EPMC2573345 | biostudies-literature
Unknown Sequence diversity and molecular evolution of the leukotoxin (lktA) gene in bovine and ovine strains of Mannheimia (Pasteurella) haemolytica.
| S-EPMC95014 | biostudies-literature
Unknown Identification of Mannheimia haemolytica adhesins involved in binding to bovine bronchial epithelial cells.
| S-EPMC2612293 | biostudies-literature
Unknown Two outer membrane proteins are bovine lactoferrin-binding proteins in Mannheimia haemolytica A1.
| S-EPMC5013584 | biostudies-literature
Unknown Effect of apo-lactoferrin on leukotoxin and outer membrane vesicles of Mannheimia haemolytica A2.
| S-EPMC7059318 | biostudies-literature
Unknown Mosaic structure and molecular evolution of the leukotoxin operon (lktCABD) in Mannheimia (Pasteurella) haemolytica, Mannheimia glucosida, and Pasteurella trehalosi.
| S-EPMC134752 | biostudies-literature