Bourbon and Mycbp function with Otu to promote Sxl protein expression in the <i>Drosophila</i> female germline.

ABSTRACT: In Drosophila ovaries, germ cells differentiate through several stages of cyst development before entering meiosis. This early differentiation program depends on both the stepwise deployment of specific regulatory mechanisms and on maintenance of germline sexual identity. The study of female sterile mutations that result in formation of germ cell tumors has been invaluable in identifying the mechanisms that control these developmental events. Here, we characterize the germ cell-enriched gene bourbon (bbn), null mutants of which cause the formation of a mixture of agametic ovarioles and cystic germ cell tumors. We performed proteomic analysis and found Bbn forms a complex with Ovarian tumor (Otu), a protein previously linked with regulation of the sex determination factor S

SUBMITTER: Mercer M 

PROVIDER: S-EPMC12012553 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature