Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection.

ABSTRACT:

Introduction

The biphasic dose-response behavior, also known as hormesis, is a characteristic feature of numerous natural products. It is defined by beneficial effects at low concentrations and toxicity at higher doses. This study investigates the hormetic effects of Brosimine B, a flavonoid derived from Brosimum acutifolium, on retinal cell viability under oxidative stress.

Methods

To simulate ischemic conditions, we used an oxygen-glucose deprivation (OGD) model. Retinal cells were treated with varying concentrations of Brosimine B, and analyses of cell viability, reactive oxygen species (ROS) production, and antioxidant enzyme activity were performed.

Results

Brosimine B at 10 µM significantly enhanced cell viability and reduced ROS production, likely through modul

SUBMITTER: Fonseca SSS 

PROVIDER: S-EPMC12012618 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature