Acute Blood Pressure Lowering and Risk of Ischemic Lesions on MRI After Intracerebral Hemorrhage.

ABSTRACT:

Importance

Diffusion-weighted imaging (DWI) lesions have been demonstrated in patients with subacute intracerebral hemorrhage (ICH), suggesting ischemic injury, which may be related to blood pressure (BP) reduction.

Objective

To test the hypothesis that acute intensive BP lowering is associated with DWI lesions after ICH.

Design, setting, and participants

The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial 2 (ICHADAPT-2) was a multicenter, randomized, open-label, blinded-end point trial. Between November 2012 and August 2022, patients with ICH presenting within 6 hours of onset were randomized to a systolic BP (SBP) target of less than 140 mm Hg or less than 180 mm Hg. The trial was conducted at 3 comprehensive stroke centers in Canada and Australi

SUBMITTER: Butcher KS 

PROVIDER: S-EPMC12012699 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature