Exercise performance in well-trained male mice is promoted by intermittent hyperoxia via improving metabolic properties and capillary profiles.

ABSTRACT: Although training under intermittent hyperoxia has been shown to improve exercise performance, its effect on well-trained mice remains undetermined. Voluntary run for 7 weeks increased maximal work values by 7.4-fold (Bayes factor, BF ≥ 30). Subsequently, mice underwent 4 weeks of treadmill training with (INT) or without (ET) intermittent hyperoxia (30% O₂). INT training significantly increased maximal exercise capacity compared to ET (BF ≥ 30). INT group exhibited significantly higher levels of cytochrome-c-oxidase (COX) in soleus muscle (SOL, BF ≥ 3.0). Additionally, INT enhanced 3-hydroxyacyl-CoA-dehydrogenase (HAD) levels in white gastrocnemius (Gw) and plantaris (PL) muscles compared to ET (BF ≥ 3.0). Pyruvate dehydrogenase complex (PDHc) levels were significantly higher in

SUBMITTER: Suzuki J 

PROVIDER: S-EPMC12012744 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature