Identification of Eight Histone Methylation Modification Regulators Associated With Breast Cancer Prognosis.

ABSTRACT: Histone methylation is an important epigenetic modification process coordinated by histone methyltransferases, histone demethylases and histone methylation reader proteins and plays a key role in the occurrence and development of cancer. This study constructed a risk scoring model around histone methylation modification regulators and conducted a multidimensional comprehensive analysis to reveal its potential role in breast cancer prognosis and drug sensitivity. First, 144 histone methylation modification regulators (HMMRs) were subjected to differential analysis and univariate Cox regression analysis, and nine differentially expressed HMMRs associated with survival were screened out. Next, a risk scoring model consisting of eight HMMRs was constructed using the LASSO regression algorithm,

SUBMITTER: Cao YN 

PROVIDER: S-EPMC12012758 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature