Fundamental Trade-Offs in the Robustness of Biological Systems with Feedback Regulation.

ABSTRACT: Natural biological systems use feedback regulation to effectively respond and adapt to their changing environment. Even though in engineered systems we understand how accurate feedback can be depending on the electronic or mechanical parts that it is implemented with, we largely lack a similar theoretical framework to study feedback regulation in biological systems. Specifically, it is not fully understood or quantified how accurate or robust the implementation of biological feedback actually is. In this paper, we study the sensitivity of biological feedback to variations in biochemical parameters using five example circuits: positive autoregulation, negative autoregulation, double-positive feedback, positive-negative feedback, and double-negative feedback (the toggle switch). We find that

SUBMITTER: Tran NHN 

PROVIDER: S-EPMC12012877 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature