Multi-Layer Autocatalytic Feedback Enables Integral Control Amidst Resource Competition and Across Scales.

ABSTRACT: Integral feedback control strategies have proven effective in regulating protein expression in unpredictable cellular environments. These strategies, grounded in model-based designs and control theory, have advanced synthetic biology applications. Autocatalytic integral feedback controllers, utilizing positive autoregulation for integral action, are one class of simplest architectures to design integrators. This class of controllers offers unique features, such as robustness against dilution effects and cellular growth, as well as the potential for synthetic realizations across different biological scales, owing to their similarity to self-regenerative behaviors widely observed in nature. Despite this, their potential has not yet been fully exploited. One key reason, we discuss, is that th

SUBMITTER: M Zand A 

PROVIDER: S-EPMC12012887 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature