Glucose- and glutamine-driven de novo nucleotide synthesis facilitates WSSV replication in shrimp.

ABSTRACT:

Background

Viruses rely on host metabolism to complete their replication cycle. White spot syndrome virus (WSSV), a major pathogen in shrimp aquaculture, hijacks host metabolic pathways to fulfill its biosynthetic and energetic needs. Previous studies have demonstrated that WSSV promotes aerobic glycolysis (Warburg effect) and glutaminolysis during its replication stage (12 hpi). Therefore, glucose and glutamine serve as crucial metabolites for viral replication. Additionally, de novo nucleotide synthesis, including the pentose phosphate pathway and purine/pyrimidine synthesis, is significantly activated during WSSV infection. However, the precise association between WSSV and host glucose and glutamine metabolism in driving de novo nucleotide synthesis remains unclear. This study a

SUBMITTER: Chen CY 

PROVIDER: S-EPMC12012963 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature