Dataset Information

Factors influencing the spiritual needs of patients with terminal cancer: a multicenter study in southern China.

ABSTRACT:

Background

There is limited evidence regarding the influencing factors associated with diverse types of spiritual needs in patients with terminal cancer. To investigate the spectrum of spiritual needs in patients with terminal cancer and clarify the impact of cancer -related pain, fatigue, sociodemographic characteristics on these needs.

Methods

This cross-sectional study was designed in accordance with the STROBE guidelines. Participants (N = 224) were recruited from three tertiary class A medical centers in southern China via convenience sampling. Socio-demographic, clinical profiles, spiritual needs, pain and fatigue were assessed. Univariate and multivariate analyses were performed using standardized statistical methods.

Results

Multiple linear regression analysis revealed that religious affiliation, residence, healthcare payment method, pain properties and number of pain sites significantly predicted the overall spiritual needs of patients with terminal cancer (F = 6.972, p < 0.001; Durbin-Watson statistic = 1.642; adjusted R² = 0.337). Subgroup analyses demonstrated distinct predictors for specific spiritual domains: pain severity predicted needs for love and connection and hope and peace, while pain properties and multifocal pain influenced meaning and purpose and overall spiritual needs (p < 0.001; adjusted R² range: 0.273-0.386).

Conclusion

Religious affiliation and healthcare payment method emerged as prominent predictors of diverse spiritual needs in the analysis. Pain severity and multifocal pain differentially influenced specific spiritual domains. Although this study attempts to identifies patterns in spiritual needs, individual variability persists. These findings underscore the necessity of personalized spiritual care in hospice settings, tailored to the content and intensity of each patient's unique needs.

SUBMITTER: Zhu F

PROVIDER: S-EPMC12012964 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature

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Publications

Factors influencing the spiritual needs of patients with terminal cancer: a multicenter study in southern China.

Zhu Fang F Wu Zilan Z Zhu Hongyu H Liu Dun D Yang Ling L Lin Yan Y Lin Jinyuan J Ke Xi X

BMC palliative care 20250422 1

<h4>Background</h4>There is limited evidence regarding the influencing factors associated with diverse types of spiritual needs in patients with terminal cancer. To investigate the spectrum of spiritual needs in patients with terminal cancer and clarify the impact of cancer -related pain, fatigue, sociodemographic characteristics on these needs.<h4>Methods</h4>This cross-sectional study was designed in accordance with the STROBE guidelines. Participants (N = 224) were recruited from three tertia ...[more]

PMID: 40264115

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Project description:Background: This multicenter longitudinal study seeks to investigate the dynamic changes of psychological distress (PD) in nasopharyngeal carcinoma (NPC) patients during radiotherapy, and reveal the expression profiles and regulatory networks of circRNAs in these NPC patients. Methods: 282 newly diagnosed NPC patients from three hospitals in China were included. Participants completed questionnaires and provided blood samples. PD trajectories were identified via a latent class growth model (LCGM). Moreover, the factors that influence the PD trajectories were explored. Whole transcriptome sequencing was performed to investigate genetic factors. The real-time quantitative PCR was applied to validate circRNAs. We predicted the target mirnas, target Mrnas and target RNA-binding proteins (RBPs) of the top 10 malregulated circrnas. Subsequently, circRNA-miRNA-mRNA (ceRNA) and circRNA-RBP networks were constructed. In addition, the role of circRNA and target mRNA parent genes was predicted by KEGG and GO analysis. Results: LCGM identified two of the most important PD trajectories during radiotherapy in NPC patients: Class 1 “decline distress group” (11.0%) and Class 4 “rise distress group” (20.3%). Household monthly per capita income, coping strategies, and perceived social support emerged as important predictors of PD trajectories. Regarding genetic factors, 600 circRNAs and 123 miRNAs were identified as being significantly differentially expressed. Notably, hsa_circ_0004277 demonstrated significant differences between patients in the rise and decline distress groups (P < 0.01). ceRNA and RBP networks may influence the pathophysiology of PD in NPC patients undergoing radiotherapy. Conclusion: This study unraveled that PD trajectories in NPC patients during radiotherapy were heterogeneous, indicating the need for screening and timely interventions within this population. Furthermore, the expression patterns of ceRNA and circRNA–RBP networks and pathways related to these networks suggested a potential role of circRNAs in developing PD among NPC patients receiving radiotherapy.

Dataset Information

Factors influencing the spiritual needs of patients with terminal cancer: a multicenter study in southern China.

Background

Methods

Results

Conclusion

Publications

Factors influencing the spiritual needs of patients with terminal cancer: a multicenter study in southern China.

Similar Datasets

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