The mechanism of Weiqi decoction treating gastric cancer: a work based on network pharmacology and experimental verification.

ABSTRACT:

Background

Weiqi Decoction (WQD) is an empirical prescription traditionally used in China for the treatment of precancerous gastric cancer (GC) lesions. This study aimed to elucidate the potential pharmacological mechanisms of WQD in GC therapy.

Methods

Active ingredients, corresponding targets, and GC-related genes were identified using public databases. A protein-protein interaction (PPI) network was constructed via the STRING database, and functional enrichment analyses were conducted using the DAVID platform. Gene expression and survival analyses were performed using the GEPIA database. Molecular docking was conducted with AutoDock Vina and visualized using PyMOL. The effects of WQD on GC cell viability, proliferation, migration, and invasion were evaluated through CCK-8

SUBMITTER: Huang X 

PROVIDER: S-EPMC12012975 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature