Improvement of the inflammation-damaged intestinal barrier and modulation of the gut microbiota in ulcerative colitis after FMT in the SHIME® model.

ABSTRACT:

Background

Fecal microbiota transplantation (FMT) seems to be a promising approach in ulcerative colitis (UC) management with the aim of repopulating a patient's dysbiotic microbiota with beneficial bacteria and restore its metabolic activity to its healthy characteristics. Metabolites present after FMT may improve the function and integrity of the intestinal barrier, reduce inflammation, and thus induce remission in an UC patient. In this study we evaluated whether the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) model may be a suitable non-invasive alternative for studying and modifying the dysbiotic microbiota in UC by FMT application.

Methods

SHIME® model was used to investigate microbial and metabolic changes in the gut microbiota of UC patient induced

SUBMITTER: Kamlarova A 

PROVIDER: S-EPMC12013018 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature