Maternal obesity and the incidence of large-for-gestational-age newborns in isolated hypothyroxinemia pregnancies: a comparative cohort study.

ABSTRACT:

Background

The synergistic impact of isolate maternal hypothyroxinaemia (IMH) and other modulators on fetal growth outcomes is unknown. This study was aimed to determine whether third trimester IMH [free thyroxine level (FT4) below the the 5th percentile and thyroid stimulating hormone (TSH) between the 5th and 95th percentiles] and prenatal body mass index (BMI) jointly increase the risk of large for gestational age (LGA) deliveries.

Methods

A retrospective analysis was conducted on 11,478 Chinese pregnant women with laboratory data (including thyroid hormone levels and routine biochemical tests) and hospitalization records from a specialized hospital.

Results

The prevalence of obesity (BMI ≥ 30 kg/m²) and IMH was 20.1% (2312/11478) and 4.5% (519/11478), r

SUBMITTER: Zhang B 

PROVIDER: S-EPMC12013030 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature