A study on the impact of neoadjuvant therapy on molecular subtype conversion in breast cancer.

ABSTRACT:

Purpose

The aim of this study was to examine molecular subtype conversions in patients who received neoadjuvant therapy.

Methods and materials

A retrospective analysis was performed on 316 patients who underwent neoadjuvant therapy at Zhongnan Hospital of Wuhan University between March 2017 and October 2024. The study included data from patients with confirmed pathological residual disease at the primary site post-surgery, alongside complete receptor status and detailed information on the neoadjuvant treatment regimen administered before and after therapy. Univariate and multivariate logistic regression analyses were employed to identify factors influencing molecular subtype heterogeneity before and after neoadjuvant therapy.

Results

Of the 316 patients who received n

SUBMITTER: Zhang RZ 

PROVIDER: S-EPMC12013096 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature