Multi-kingdom gut microbiota dysbiosis is associated with the development of pulmonary arterial hypertension.

ABSTRACT:

Background

Gut microbiota dysbiosis has been implicated in pulmonary arterial hypertension (PAH). However, the exact roles and underlying mechanisms of multi-kingdom gut microbiota, including bacteria, archaea, and fungi, in PAH remain largely unclear.

Methods

The shotgun metagenomics was used to analyse multi-kingdom gut microbial communities in patients with idiopathic PAH (IPAH) and healthy controls. Furthermore, fecal microbiota transplantation (FMT) was performed to transfer gut microbiota from IPAH patients or monocrotaline (MCT)-PAH rats to normal rats and from normal rats to MCT-PAH rats.

Findings

Gut microbiota analysis revealed substantial alterations in the bacterial, archaeal, and fungal communities in patients with IPAH compared with healthy controls. Not

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12013117 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature