Ultrasound-cavitation-enhanced drug delivery via microbubble clustering induced by acoustic vortex tweezers.

ABSTRACT: The application of acoustic vortex tweezers (AVT) in conjunction with ultrasound (US) cavitation pulses presents a promising noninvasive approach for the delivery of high concentrations of therapeutic agents. This methodology facilitates the aggregation of drug-loaded microbubbles (MBs) into clusters, which are subsequently destroyed to release their contents. Nevertheless, prior investigations have not thoroughly examined the resonance frequency and cavitation activity of MB clusters, critical factors that could enhance the efficiency of payload release. Theoretically, the resonance frequency of an MB cluster is expected to approximate that of a single large bubble of comparable size, thus being significantly lower than that of the individual MBs constituting the cluster. Accordingly, thi

SUBMITTER: Fan CH 

PROVIDER: S-EPMC12013124 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature