Kaili sour soup in alleviation of hepatic steatosis in rats via lycopene route: an experimental study.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases, with a range of manifestations, such as hepatic steatosis. Our previous study showed that Kaili Sour Soup (KSS) significantly attenuated hepatic steatosis in rats. This study explored the main components of KSS and the mechanisms by which it exerts its protective effects against NAFLD.

Methods

Twenty-four 6-week-old male Sprague-Dowley (SD) rats were randomly assigned to three treatments: feeding a normal standard diet, a high-fat diet, or a high-fat diet plus gavage KSS. The effects of KSS treatment on hepatic lipid accumulation were assessed using biochemical, histological, and molecular experiments. The amounts of KSS ingredients were measured using biochemical assays.

SUBMITTER: Li Y 

PROVIDER: S-EPMC12013139 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature