Associations of blood RNA biomarkers and circulating tumour cells in patients with previously untreated metastatic colorectal cancer.

ABSTRACT:

Background

In patients with metastatic colorectal cancer, analysis of the number of basal circulating tumour cells (bCTCs) has been shown to be a strong prognostic indicator. In this study, we aim to explore the potential associations between whole blood mRNA and microRNA expression profiles and bCTC counts, tumour mutations and prognosis in untreated metastatic colorectal cancer patients.

Methods

A total of 151 patients previously screened for inclusion in two clinical trials (VISNÚ1 and VISNÚ2) were enrolled in this study. Real-time quantitative PCR (qPCR) analyses were performed to determine the whole blood expression of selected RNAs (mRNAs and microRNAs) involved in the metastatic process. The CellSearch system was used to enumerate circulating tumour cells. The primary

SUBMITTER: Valladares-Ayerbes M 

PROVIDER: S-EPMC12013160 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature