Global dissemination of conjugative virulence plasmids co-harboring hypervirulence and multidrug resistance genes in <i>Klebsiella pneumoniae</i>.

ABSTRACT: Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) has led to a high mortality rate in the clinical setting and garnered significant attention in the clinical and scientific communities. It is still not clear which major mechanisms mediate the rapid evolution of hvKp in clinical settings since the plasmid-encoding hypervirulence phenotype is considered non-conjugative. In this study, we revealed a conjugative plasmid, p16HN200-Vir, encoding virulence-associated iuc operon (iucABCDiutA) and resulting in a hypervirulent phenotype. In silico analysis of Kp strains from NCBI predicted a total of 94 p16HN200-Vir-like conjugative virulence plasmids. These sequences were identified in 19 sequence types (STs) of the host with signifi

SUBMITTER: Xu Q 

PROVIDER: S-EPMC12013265 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature