A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49.

ABSTRACT: Appropriate response to nutritional stress is critical for animal survival and metabolic health. To better understand regulatory networks that sense and respond to nutritional availability, we developed a quantitative RT-PCR strategy to monitor changes in metabolic gene expression resulting from short-term food deprivation (fasting) in Caenorhabditis elegans. Examining 97 fat and glucose metabolism genes in fed and fasted animals, we identified 18 genes significantly influenced by food withdrawal in all developmental stages. Fasting response genes fell into multiple kinetic classes, with some genes showing significant activation or repression just 1 h after food was removed. As expected, fasting stimulated the expression of genes involved in mobilizing fats for energy production, including

SUBMITTER: Van Gilst MR 

PROVIDER: S-EPMC1201344 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature