Dataset Information
Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival.
Ontology highlight
ABSTRACT:
SUBMITTER: Zein L
PROVIDER: S-EPMC12013452 | biostudies-literature | 2025 May
REPOSITORIES: biostudies-literature
Publications
Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival.
Autophagy 20250102 5
Lysosomes are the major cellular organelles responsible for nutrient recycling and degradation of cellular material. Maintenance of lysosomal integrity is essential for cellular homeostasis and lysosomal membrane permeabilization (LMP) sensitizes toward cell death. Damaged lysosomes are repaired or degraded via lysophagy, during which glycans, exposed on ruptured lysosomal membranes, are recognized by galectins leading to K48- and K63-linked poly-ubiquitination (poly-Ub) of lysosomal proteins fo ...[more]