CovidTGI: A tool to investigate the temporal genetic instability of SARS-CoV-2 variants.

ABSTRACT: The COVID-19 pandemic has underscored the need for fast and accurate epidemiology, particularly due to the high observed mutation frequency in SARS-CoV-2. This study aims to explore the evolution of SARS-CoV-2 through a global analysis. To facilitate a comparative analysis of temporal mutation data, we developed CovidTGI, a Shiny web application. CovidTGI provides insights into observed mutation frequencies and the temporal relationships among mutations across various clades in different geographical regions. Our tool relies on a database that includes 2 million samples obtained from the National Center for Biotechnology Information (NCBI), along with 500 in-house Sicilian samples collected between May 2021 and June 2022. From this smaller group of samples, we identified key variants that

SUBMITTER: Privitera GF 

PROVIDER: S-EPMC12013479 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature