<i>In vitro</i> microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier.

ABSTRACT:

Background

Non-absorbed dietary emulsifiers, including carboxymethylcellulose (CMC), directly disturb intestinal microbiota, thereby promoting chronic intestinal inflammation in mice. A randomised controlled-feeding study (Functional Research on Emulsifiers in Humans, FRESH) found that CMC also detrimentally impacts intestinal microbiota in some, but not all, healthy individuals.

Objectives

This study aimed to establish an approach for predicting an individual's sensitivity to dietary emulsifiers via their baseline microbiota.

Design

We evaluated the ability of an in vitro microbiota model (MiniBioReactor Arrray, MBRA) to reproduce and predict an individual donor's sensitivity to emulsifiers. Metagenomes were analysed to identify signatures of emulsifier sensit

SUBMITTER: Rytter H 

PROVIDER: S-EPMC12013555 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature