Delivery room dextrose gel for preterm hypoglycaemia (the GEHPPI study): a randomised placebo-controlled trial.

ABSTRACT:

Objective

Early hypoglycaemia at the time of neonatal intensive care unit (NICU) admission is common in very/extreme preterm infants. This study aimed to determine whether buccal dextrose gel in the delivery room (DR) would improve rates of early hypoglycaemia in this population.

Design

Randomised, blinded, placebo-controlled trial.

Setting

Four level-3 and one level-2 neonatal units.

Patients

Inborn infants≤32+0 weeks gestational age (GA).

Interventions

Infants were randomised to 40% dextrose or placebo gel in the DR (≤29+0 GA: 0.5 mL gel, ≥29+1 GA: 1 mL gel).

Main outcome measure

Hypoglycaemia (<1.8 mmol/L) measured at the time of first intravenous access at NICU admission.

Results

Between November 2020 and August 2022, the recruitment ra

SUBMITTER: King G 

PROVIDER: S-EPMC12013586 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature