Neonatal hyperinsulinism: a retrospective study of presentation and management in a tertiary neonatal intensive care unit in the UK.

ABSTRACT:

Objective

Reports of hyperinsulinism typically focus on infants managed by highly specialised services. However, neonates with hyperinsulinism are initially managed by neonatologists and often not referred to specialists. This study aimed to characterise the diversity in presentation and management of these infants.

Setting

Level 3 neonatal intensive care.

Patients

Neonates with hyperinsulinism, defined as blood glucose <2.8 mmol/mL and insulin level >6 pmol/L.

Design

7-year retrospective study (January 2015-December 2021).

Results

99 cases were identified: severe-treated with diazoxide (20%), moderate-clinically concerning hyperinsulinism not treated with diazoxide (30%), mild-biochemical hyperinsulinism (50%). Birth weight z-score

SUBMITTER: Kalogeropoulou MS 

PROVIDER: S-EPMC12013591 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature