Leptin regulates parathyroid hormone secretion through CaSR-ERK1/2 signaling.

ABSTRACT: Leptin and parathyroid hormone (PTH) are key regulators of metabolic and mineral homeostasis. Leptin, primarily secreted by adipose tissue, controls appetite and energy expenditure through its receptors in the central nervous system, while PTH maintains serum calcium and phosphate balance and skeletal integrity by acting on kidneys and bone. The calcium sensing receptor (CaSR) plays a central role in parathyroid function and PTH secretion. While clinical and experimental evidence suggests reciprocal interactions between leptin and PTH, where hyperleptinemia and disrupted leptin signaling in obesity may exacerbate conditions such as secondary hyperparathyroidism, direct effects of leptin on the parathyroid remain poorly defined. We now show that leptin receptor-deficient db/db mice exhibit

SUBMITTER: Kilav-Levin R 

PROVIDER: S-EPMC12013696 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature