Patient Reported Outcomes in Primary Sclerosing Cholangitis: An Australian Perspective.

ABSTRACT:

Background and aims

Primary sclerosing cholangitis (PSC) is a rare, cholestatic liver condition that has a significant association with inflammatory bowel disease (IBD) and impaired health-related quality of life (HRQOL). We aimed to characterise and compare validated PSC and IBD patient-reported outcomes (PRO) and determine if PRO correlated with the severity of liver disease.

Methods

We conducted a multicentre, prospective cohort study in Australia enrolling adult patients with PSC from December 2019 to August 2023. Consecutive patients completed a baseline validated PSC PRO questionnaire and a short IBD questionnaire (SIBDQ) if they had concomitant IBD. Linear regression was used to explore factors associated with poor HRQOL and the association between each HRQOL domain a

SUBMITTER: Tan N 

PROVIDER: S-EPMC12013783 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature