Association Between Viral Replication Activity and Postoperative Recurrence of HBV-Related Hepatocellular Carcinoma.

ABSTRACT:

Background

Baseline viral replication activity influences the risk of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B virus (HBV) infection.

Aims

To evaluate the impact of baseline viral replication activity on recurrence in HBV-related HCC after curative resection.

Methods

A multinational retrospective cohort of 2384 patients with very early or early-stage HBV-related HCC who consecutively underwent curative resection and received antiviral therapy (AVT) between 2010 and 2018 was analysed. Patients were categorised into ongoing-AVT (previously on AVT with viral suppression) and initiation-AVT (initiated AVT at the time of resection) groups. HCC recurrence was compared between these two groups based on baseline viral replication activit

SUBMITTER: Heo S 

PROVIDER: S-EPMC12013788 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature