Interictal discharges spread along local recurrent networks between tubers and surrounding cortex.

ABSTRACT: The presence of interictal epileptiform discharges on EEG may indicate increased epileptic seizure risk. In highly epileptogenic lesions, such as cortical tubers in tuberous sclerosis, these discharges can be recorded with intracranial stereotactic EEG as part of the evaluation for epilepsy surgery. Yet the network mechanisms that underwrite the generation and spread of these discharges remain poorly understood. Here, we investigate the dynamics of interictal epileptiform discharges using a combination of quantitative analysis of invasive EEG recordings and mesoscale neural mass modelling of cortical dynamics. We first characterise spatially organised local dynamics of discharges recorded from 36 separate tubers in eight patients with tuberous sclerosis. We characterise these dynamics with

SUBMITTER: Tumpa S 

PROVIDER: S-EPMC12013798 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature