Epidemiological and spatial analysis of newly diagnosed HIV-1/AIDS patients before antiretroviral therapy in Ningxia from 2020 to 2021.

ABSTRACT: The high mutability of human immunodeficiency virus type 1 (HIV-1) and the widespread use of antiretroviral drugs have rendered genetic diversity and pre-treatment drug resistance (PDR) significant obstacles to the success of antiretroviral therapy (ART). However, the research on the epidemiological and spatial distribution characteristics of PDR in Ningxia is still insufficient. A cross-sectional study utilized pre-treatment blood samples collected between 2020 and 2021 from the biorepository in May 2024. Partial pol gene sequences were obtained through plasma collection and RNA extraction. Drug resistance analysis was performed using the Stanford University HIVdb algorithm. Molecular network were constructed using Cytoscape 3.10.0. Spatial analysis and visualization were further conducte

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12013917 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature