Unraveling new therapeutic targets in ankylosing spondylitis: Multi-omics Mendelian randomization on immune cells, metabolites, and inflammation proteins.

ABSTRACT: This study aims to identify novel immunological, metabolic, and inflammatory determinants of ankylosing spondylitis (AS) using Mendelian randomization (MR), offering new insights into its pathogenesis and potential therapeutic interventions. Employing a bidirectional, secondary validation two-sample MR, this study investigated causal associations among 1400 serum metabolites, 731 immune cell traits, and 91 circulating inflammatory proteins with AS. Instrumental variables were identified using PLINK for minimal linkage disequilibrium, applying strict significance thresholds. Various MR methodologies, including inverse variance weighted, weighted median, and MR Egger, were applied to validate causal links. Sensitivity analyses, incorporating heterogeneity and pleiotropy tests, were performed

SUBMITTER: Du K 

PROVIDER: S-EPMC12014029 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature