Exercise improves load bearing bone structural properties in female secreted protein acidic and rich in cysteine (SPARC) null mice but not in males.

ABSTRACT: Secreted protein acidic and rich in cysteine (SPARC) is the most abundant glycoprotein in bone and is thought to play a critical role in bone remodeling and homeostasis. However, the effect of SPARC in relation to gender and exercise on bone quality is not well understood. The purpose of this study was to quantify differences in the structural and biomechanical properties between calvarial and femoral bone from male and female wild-type (WT) and SPARC null (SPARC^(-/-)) mice as well as the ability of exercise to rescue bone health. Male and female WT and transgenic SPARC^(-/-) mice were given either a fixed or rotating running wheel for exercise. Bone structural, biomechanical, and morphological parameters were quantified using micro computed tomography, push out testin

SUBMITTER: Kaneda G 

PROVIDER: S-EPMC12014150 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature