In Silico Design and Characterization of a Multiepitope Vaccine Candidate Against <i>Brucella canis</i> Using a Reverse Vaccinology Approach.

ABSTRACT: Brucella canis is a Gram-negative bacterium that causes canine brucellosis, a zoonotic disease with serious implications for public health and the global economy. Currently, there is no effective preventive vaccine for B. canis. Control measures include diagnostic testing, isolation, and euthanasia of infected animals. However, these measures face significant limitations, such as diagnostic challenges, ethical concerns, and limited success in preventing transmission. Epidemiologically, canine brucellosis exhibits seroprevalence rates ranging from less than 1% to over 15%, with higher rates reported in stray dogs and regions of low socioeconomic development. This study employed a reverse vaccinology approach to design and characterize a multiepitope vaccine candidate against <

SUBMITTER: Arriagada V 

PROVIDER: S-EPMC12014272 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature