Clinical characteristics and risk factors for escalation to anaphylaxis from non-severe drug hypersensitivity reaction.

ABSTRACT:

Background

Drug hypersensitivity reaction (DHR) poses significant challenges in clinical practice, with some patients experiencing more severe reactions upon re-exposure. Understanding the factors contributing to escalation into more severe reactions is crucial for improving patient safety. This study aimed to investigate the clinical characteristics and risk factors associated with the progression from non-severe DHR to anaphylaxis.

Methods

A multicenter retrospective study was conducted using data from a drug-induced anaphylaxis registry across 10 university hospitals in Korea. Clinical data, including information on culprit drugs, DHR history, and the severity of reactions, were assessed.

Results

Among 494 cases of drug-induced anaphylaxis, 417 cases (84.4%) occurr

SUBMITTER: Rhyou HI 

PROVIDER: S-EPMC12014396 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature