Characterizing circulating biomarkers for childhood dementia disorders: A scoping review of clinical trials.

ABSTRACT: Childhood dementias, a group of neurological disorders are characterised by neurocognitive decline, with physical and psychosocial impacts for individuals. With therapy available for <5 ​% of childhood dementias, there is a high level of unmet need. Integration of biomarkers in clinical trials are important to characterize distinctive biological activities and interrogate targets for therapeutic development. This study reviewed four clinical trial registries to examine circulating biomarkers in childhood dementias. Findings from 262 studies were synthesized across 49/72 (68 ​%) childhood dementia disorders. Disease-related biomarkers were associated with 1) the primary pathophysiology 2) downstream pathogenic events 3) drug-related pharmacokinetics, safety and/or tolerability. The predomin

SUBMITTER: D'Silva A 

PROVIDER: S-EPMC12014410 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature