Urinary metabolomics analysis based on LC-MS for the diagnosis and monitoring of acute coronary syndrome.

ABSTRACT:

Background

Acute coronary syndrome (ACS) is a cardiovascular disease caused by acute myocardial ischemia. The aim of this study was to use urine metabolomics to explore potential biomarkers for the diagnosis of ACS and the changes in metabolites during the development of this disease.

Methods

Urine samples were collected from 81 healthy controls and 130 ACS patients (103 UA and 27 AMI). Metabolomics based on liquid chromatography-mass spectrometry (LC-MS) was used to analyze urine samples. Statistical analysis and functional annotation were applied to identify potential metabolite panels and altered metabolic pathways between ACS patients and healthy controls, unstable angina (UA), and acute myocardial infarction (AMI) patients.

Results

There were significant differen

SUBMITTER: Liu J 

PROVIDER: S-EPMC12014464 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature