Bovine colostrum prevents formula-induced gut microbiota dysbiosis in preterm pigs.

ABSTRACT:

Background

Preterm birth and formula feeding increase the risk of necrotizing enterocolitis (NEC), a gut inflammatory disease known to be associated with gut microbiota (GM) changes in infants. Supplemental bovine colostrum may protect against formula-induced NEC via GM changes. We hypothesised that feeding colostrum before, after, or during formula feeding affects NEC sensitivity via changes to GM.

Methods

Colonic GM (profiled by 16S ribosomal RNA gene amplicon sequencing) was compared in preterm pigs fed colostrum for 4 days, either before, after, or together with formula feeding for 4 days. Correlations between GM and gut parameters were assessed on day 5 or 9.

Results

Both exclusive and partial colostrum feeding induced higher GM diversity, lower Enterococcus abun

SUBMITTER: Yang L 

PROVIDER: S-EPMC12014488 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature