A longitudinal study of hippocampal subfield volumes and hippocampal glutamate levels in antipsychotic-naive first episode psychosis patients.

ABSTRACT:

Background

Previous studies have implicated hippocampal abnormalities in the neuropathology of psychosis spectrum disorders. Reduced hippocampal volume has been reported across all illness stages, and this atrophy has been hypothesized to be the result of glutamatergic excess. To test this hypothesis, we measured hippocampal subfield volumes and hippocampal glutamate levels in antipsychotic naïve first episode psychosis patients (FEP) and the progression of volume decline and changes in glutamate levels over a 16-week antipsychotic drug (APD) trial. We aimed to determine if subfield volumes at baseline were associated with glutamate levels, and if baseline glutamate levels were predictive of change in subfield volumes over time.

Methods

We enrolled ninety-three medication-na

SUBMITTER: Nelson EA 

PROVIDER: S-EPMC12014507 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature